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Ownership Profile
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Shareholder Breakdown
  Holders Values ($) % O/S Shares
Institution 54 49,945,763.00 38.38 25,745,239
Mutual Fund 28 19,434,612.00 14.93 10,017,840

Institutional Shareholder Rotation
  Holders Values Change ($) % O/S Shares Change
Buyers 33 20,112,661.00 25.65 10,367,351
Sellers 12 -8,590,110.00 7.46 -4,427,893
Net -- 11,522,551.00 18.19 5,939,458

Institutional Shareholder Concentration
  Values ($) % O/S Shares
Top 10 Inst. 44,631,237 34.29 23,005,792
Top 20 Inst. 47,954,066.00 36.85 24,718,591
Top 50 Inst. 49,940,000.00 38.37 25,742,268
Total Inst. 49,945,763.00 38.38 25,745,239

Institutional Shareholder Style
  Holders Values ($) % O/S Shares
Growth 28 5,201,777 10.41 2,681,329
GARP 8 16,561,485 33.16 8,536,848
Index 5 7,221,697 14.46 3,722,524
Value 5 2,842,668 5.69 1,465,293
Yield 5 215,340 0.43 111,000
Aggressive Growth 3 17,902,796 35.84 9,228,245

Top Holders: Institutional Investor
  Shares Held % O/S Shares Change Filing Date
Perceptive Advisors LLC 5,630,000 8.39 5,630,000 03/31/2013
Baker Bros. Advisors LLC 4,775,787 7.12 1,738,385 03/31/2013
Columbia Wanger Asset Management LLC 4,302,458 6.41 -3,723,842 03/31/2013
VHCP Management LLC 2,516,870 3.75 0 03/31/2013
The Vanguard Group, Inc. 2,016,957 3.01 350,381 03/31/2013
BlackRock Fund Advisors 1,414,899 2.11 402,844 03/31/2013
Royce & Associates LLC 710,000 1.06 0 03/31/2013
TFS Capital LLC 608,742 0.91 274,908 03/31/2013
Jacobs Levy Equity Management, Inc. 588,829 0.88 123,179 03/31/2013
J. Goldman & Co. LP 441,250 0.66 441,250 03/31/2013
Goldman Sachs & Co. 370,446 0.55 370,446 03/31/2013
Deere & Co. Pension Fund 281,559 0.42 281,559 03/31/2013

Ownership data is provided by FactSet, a third party service, and Chelsea Therapeutics International, Ltd. does not maintain or provide information directly to this service.